Evidence
Bioglass means: Osteostimulation
01
What is Bioglass?
Bioglass 45S5 is a ceramic biocompatible material composed of:
45 wt% SiO2, 24.5 wt% CaO, 24.5 wt% Na2O, 6.0 wt% P2O5
02
What is Osteostimulation?
Osteostimulation is the proven ability of Bioglass to activate genes which regulate osteoblast differentiation and proliferation.
03
How does it work?
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Stimulation of osteoblasts and precursor cells (ES cells, fetal cells, adult primary cells) by critical concentrations of calcium and silicate ions released as the bioglass begins to dissolve
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The mechanisms of cell stimulation originate from cellular interaction with the ionic dissolution products released from VetFuse during its absorption
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Up-regulation of several gene families associated with osteoblast activity:
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- Growth factors (including IGF-II and VEG-F)
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- Transcription factors and cell cycle regulators
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- Apoptosis regulators
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- Cell surface antigen and receptors
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- Signal transduction molecules
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ECM expression
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04
What it means for the patient:
Faster, reliable, and stronger bone formation throughout the defect
Scientific Evidence
The following characteristics of Bioglass have been scientifically tested via multiple in-vivo and in-vitro studies:
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Superior Resorption Profile
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Highly Osteoconductive
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Osteostimulative
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Angiogenic Potential
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Antimicrobial
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